Natural and bioinspired excipients for dry powder inhalation formulations

Particulate Interactions in Dry Powder Formulations for Inhalation Particulate Interactions in Dry Powder Formulations for Inhalation

Optimization of the aerosolization properties of an inhalation dry powder based on selection of excipients.

The aim of this study was to investigate the influence of formulation excipients on physical characteristics of inhalation dry powders prepared by spray-drying. The excipients used were a series of amino acids (glycine, alanine, leucine, isoleucine), trehalose and dipalmitoylphosphatidylcholine (DPPC). The particle diameter and the powder density were assessed by laser diffraction and tap densi...

Dry powder inhalation: past, present and future.

INTRODUCTION Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficient dispersion principles. Therefore, particle engineering and powder processing are increasingly applied to achieve acceptable lung deposition with these poorly designed inhalers. Areas covered: The consequences of ...

Natural Excipients: Uses of Pharmaceutical Formulations

With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in their formulations. Pharmaceutical formulation development involves various components in addition to the active pharmaceutical ingredients. Nature has provided us a wide variety of materials to help improve and sustain the health of all living things either directly or ind...

Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide

Prothionamide (PTH), a second line antitubercular drug is used to administer in conventional oral route. However, its unpredictable absorption and frequent administration limit its use. An alternate approach was thought of administering PTH through pulmonary route in a form of nanoparticles, which can sustain the release for several hours in lungs. Chitosan, a bio-degradable polymer was used to...